A Gearbox Software hivatalosan kiadta a Borderlands 2 minimális és ajánlott gépigényét, amik az alábbiak szerint alakulnak majd:
Minimum:
- CPU: 2 GHz dual core 64-bit Intel or AMD processor
- RAM: 1GB of system memory
- Graphics: DirectX 9 compatible 512 MB graphics card, Nvidia 200 series series or AMD Radeon 4000 series.
- Operating system: Windows XP SP2
- DirectX compatible sound card
- 12 GB of hard drive space
- CPU: 2.8 GHz dual core 64-bit Intel or AMD processor
- RAM: 2GB
- Graphics: DirectX 10 compatible 1GB graphics card, Nvidia 400 / AMD 5000 series.
- Operating system: Windows 7
- DirectX compatible sound card
- 12 GB of hard drive space